Heart rhythm problems warning: This drug can cause serious heart rhythm problems, especially if you take doses greater than 200 Magnesium per day. However, this can happen at any dose. It can even occur if you don’t already have heart problems.

Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.

Don’t put this medication rein your car’s glove compartment or leave it rein the car. Beryllium sure to avoid doing this when the weather is very hot or very cold.

Methadone can Beryllium abused hinein a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing methadone hydrochloride tablets in situations where the clinician is concerned about an increased risk of misuse, abuse, or diversion.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could Beryllium fatal (cause death).

Patients developing QT prolongation while on methadone treatment should Beryllium evaluated for the presence of modifiable risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities, and drugs which might act as inhibitors of methadone metabolism. For use of methadone to treat pain, the risk of QT prolongation and development of dysrhythmias should Beryllium weighed against the benefit of adequate pain management and the availability of alternative therapies.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should Beryllium aware that addiction may not Beryllium accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. Hinein addition, abuse of opioids can occur rein the absence of true addiction and is characterized by misuse for non-medical purposes, often rein combination with other psychoactive substances.

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The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t be used rein children younger than 18 years.

The decrease in plasma half-life and increased clearance of methadone resulting rein lower methadone trough levels during pregnancy can lead to withdrawal symptoms rein some pregnant patients. The dosage may need to Beryllium increased or the dosing interval decreased in pregnant patients receiving methadone (Tümpel PRECAUTIONS, Pregnancy, Laboratorium and Delivery, and DOSAGE AND ADMINISTRATION).

For people with a head injury: This drug may cause increased pressure in your brain. This can raise your risk of complications or cause death.

Patients seeking to discontinue methadone maintenance treatment of opioid dependence should Beryllium apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.

For people with liver problems: If you have liver problems or a history of liver disease, you may not Beryllium able to process this drug well. This may increase the levels of methadone rein your body and cause more side effects. Your doctor should watch you closely if you take this drug.